Nephrology Center of Excellence

Supporting patients living with a rare nephrology condition

Orsini’s Nephrology Center of Excellence launched in 2020 with our first program for primary hyperoxaluria type 1. Today we support multiple nephrology programs across several rare conditions. Our dedicated Therapy Care Teams work with the physician’s office and insurance on a patient’s behalf so that our patients and their family have more time to focus on their treatment and quality of life. We are here to listen, provide counseling on treatment, including side-effect management, and assist with sourcing third-party financial assistance.

Explore Our Nephrology Therapies

Benefits

Improving the Patient Experience, Every Time

Dedicated Care Team

Receive personalized support from a dedicated Therapy Care Team, including a primary pharmacy contact, clinical education, side-effects management, and scheduled refill calls.

Home Health Nursing

Access nationwide nursing support for in-home treatment or self-administration training. Our nurses provide clinical support to help patients achieve their treatment goals.

Insurance Coverage

Secure treatment coverage with assistance navigating payor and plan requirements. Our team proactively works with prescribers to obtain prior authorization and support appeals.

Free Care Overnight Shipping

Ensure medication and essential medical supplies arrive when and where patients need them through coordination across prescribers, patients, and care teams to arrange free overnight shipping.

Financial Assistance

Minimize financial exposure through financial assistance programs. We successfully identify and assist in enrolling patients into manufacturer co-pay and foundation support programs.

24/7/365 Access to a Pharmacist

Gain continuous access to a pharmacist, 24/7/365, ensuring ongoing care and clinical support for patients and prescribers to achieve better outcomes.

Support

Nephrology Conditions Supported

Explore the rare nephrology conditions Orsini supports below.

About Homozygous Cystinuria

Homozygous cystinuria is a rare genetic disorder characterized by the presence of two identical mutations in the genes responsible for cystine transport in the kidneys. This results in impaired reabsorption of cystine, leading to its excessive accumulation in the urine. Cystine forms crystals that can combine to create kidney stones, causing recurrent and often painful episodes of nephrolithiasis. Individuals with homozygous cystinuria face an increased risk of kidney damage and related complications.

Homozygous Cystinuria Therapies Supported

Full Name	tiopronin
Drug	Tiopronin
Manufacturer	Generic
Route of Administration	Oral
Site of Care	Home
Approved Indication	In combination with high fluid intake, alkali, and diet modification, for the prevention of cystine stone formation in adults and pediatric patients 9 years of age and older with severe homozygous cystinuria, who are not responsive to these measures alone
Disease	Homozygous Cystinuria
Therapeutic Area	Nephrology
Enrollment Form Link	Tiopronin Enrollment Form
Phone Number	800-764-0147
Fax Number	877-848-6579
Product Website

About Primary Hyperoxaluria Type 1 (PH1)

Primary Hyperoxaluria Type 1 is an ultra-rare genetic disease characterized by the overproduction of oxalate, a waste product that usually is eliminated by the kidneys and excreted in the urine. The excess production of oxalate results in the deposition of calcium oxalate crystals in the kidneys and urinary tract and can lead to the formation of painful and recurrent kidney stones, nephrocalcinosis, progression to kidney failure, and systemic organ dysfunction. It is estimated that PH1 affects one to three individuals per million in the United States and Europe.

PH1 Therapies Supported

Full Name	Oxlumo® (lumasiran)
Drug	Oxlumo
Manufacturer	Alnylam Pharmaceuticals
Route of Administration	Subcutaneous
Site of Care	Home or Healthcare Facility
Approved Indication	The treatment of primary hyperoxaluria type 1 (PH1) to lower urinary oxalate levels in pediatric and adult patients
Disease	Primary Hyperoxaluria Type 1 (PH1)
Therapeutic Area	Nephrology
Enrollment Form Link	Oxlumo Enrollment Form
Phone Number	800-460-5217
Fax Number	877-276-8563
Product Website	oxlumo.com